Social interaction is measured by how the mouse interacts with a stranger mouse introduced in the opposite side of a test box. Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) reject any role for thiomersal in autism or other neurodevelopmental disorders.īehaviors measured in these models include approach to olfactory pheromones emitted by other mice, approach to familiar and new conspecifics, reciprocal social interactions, ultrasonic vocalizations, communal nesting, sexual and parenting behaviors, territorial scent marking, and aggressive behaviors, as well as motor behaviors such as gait. The current scientific consensus is that no convincing scientific evidence supports these claims, and major scientific and medical bodies such as the Institute of Medicine and World Health Organization (WHO) as well as governmental agencies such as the U.S. The Norway rat has been used, for example, by Mady Hornig to implicate thiomersal in autism. Other strains of mice used include mu opioid receptor knockout mice, as well as Fmr1 knockout mice the latter are also used as animal models of Fragile X syndrome. More recent research has used the house mouse ( Mus musculus) to model autism because it is a social species. One of the more common rodent models is the Norway rat ( Rattus norvegicus). Given the complexity of autism and its etiology, researchers often focus only on single features of autism when using animal models. The development of an animal model of autism is one approach researchers use to study potential causes of autism. ( Learn how and when to remove this template message) JSTOR ( August 2021) ( Learn how and when to remove this template message).Please improve this article by adding secondary or tertiary sources.įind sources: "Animal model of autism" – news This article relies excessively on references to primary sources.
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